lunes, 14 de noviembre de 2011

MINOXIDIL AL 5% EN ESPUMA PARA EL TRATAMIENTO DE LA ALOPECIA ANDROGENÉTICA DE LA MUJER



Hace pocos días se ha publicado un estudio de no inferioridad acerca del minoxidil en espuma al 5% administrado una vez al día frente al minoxidil solución al 2% aplicado 2 veces al día para el tratamiento de la alopecia androgenética de la mujer.
Los resultados: la aplicación de espuma de minoxidil a una concentración más elevada (5%), una sola vez al día, es al menos igual de efectivo que al 2% administado 2 veces al día.
Además: mejora el cumplimiento terapéutico de la paciente y presenta menor incidencia de efectos adversos. Un dato terapéutico importante para las pacientes con alopecia androgenética.

Fuente: revista de la academia americana de Dermatología (JAAD-diciembre 2011)


J Am Acad Dermatol. 2011 Jun 21. [Epub ahead of print]

A randomized, single-blind trial of 5% minoxidil foam once daily versus 2% minoxidil solution twice daily in the treatment of androgenetic alopecia in women.

Source

Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Germany.

Abstract

BACKGROUND:

Although twice-daily application of propylene glycol-containing 2% minoxidil topical solution (MTS) stimulates new hair growth, higher concentrations of minoxidil in a once-daily, propylene glycol-free formulation may improve efficacy and reduce unpleasant side effects.

OBJECTIVE:

We sought to compare the efficacy, safety, and acceptability and to show noninferiority of once-daily 5% minoxidil topical foam (MTF) with twice-daily 2% MTS in women with androgenetic alopecia.

METHODS:

A total of 113 women with androgenetic alopecia were randomized to 24 weeks of treatment with 5% MTF or 2% MTS. The primary efficacy parameter was change from baseline in nonvellus target area hair count at week 24. Secondary end points included change in nonvellus target area hair width, overall efficacy by global photographic review as assessed by treatment-blinded evaluators and the subject herself, adverse events, and participants' assessment of product aesthetics.

RESULTS:

After 24 weeks, women randomized to 5% MTF once daily showed noninferior target area hair count and target area hair width and experienced greater, but nonsignificant, improvements in target area hair count, target area hair width, and overall efficacy by global photographic review than those randomized to 2% MTS used twice daily. 5% MTF was significantly superior to 2% MTS in participants' agreement with "the treatment does not interfere with styling my hair" (P = .002). Women randomized to 5% MTF experienced significantly lower rates of local intolerance (P = .046) especially in pruritus and dandruff compared with 2% MTS.

LIMITATION:

Because of differences in the formulations tested, study participants were not blinded to treatment.

CONCLUSIONS:

Once-daily 5% MTF is noninferior and as effective for stimulating hair growth as twice-daily 2% MTS in women with androgenetic alopecia and is associated with several aesthetic and practical advantages.
Copyright © 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
PMID:
21700360
[PubMed - as supplied by publisher]



Dr. Sergio Vañó Galván

Dermatólogo del Hospital Universitario Ramón y Cajal en Madrid y de la Clínica Grupo de Dermatología Pedro Jaén. Coordinador de la Unidad de Tricología y estudio de las alopecias del Hospital Ramón y Cajal y de la Clínica Grupo de Dermatología Jaén.
Doctor en Medicina. Profesor Honorífico de la Universidad de Alcalá.

Twitter: @sergiovanog


3 comentarios:

  1. One should Definitely use Minoxidil for Hair regrowth.

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  2. Definitivamente el Minoxidil es un medio excelente para volver a repoblar las zonas sin bello.

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  3. Excelente informacion me ha venido de perlas...saludos

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